NEUROPEPTIDE FF CAS: 99566-27-5 PHE-LEU-PHE-GLN-PRO-GLN-ARG-PHE AME PHE-LEU-PHE-GLN-PRO-GLN-ARG-PHE-NH2 NPFF NEUROPEPTIDE FF

NPFF Neuropeptide (FLFQPQRFa) ni inyamaswa z’inyamabere zifite amine neuropeptide yabanje kwitandukanya n’ubwonko bwa bovine kandi irangwa na peptide igabanya ububabare hamwe n’ibikorwa byo kurwanya antopioide na analgesia iterwa na morphine.

Mu bantu, peptide ya neuropeptide FF igizwe na gene ya NPFF.Imirasire ibiri ikubiyemo reseptor ebyiri zitandukanye (NPFF1 na NPFF2) hamwe na preursors ebyiri (NPFFA na NPFFB) zashyizwe mu matungo menshi y’inyamabere.

Neuropeptide FF (NPFF) na peptide bifitanye isano na RFamide yasohowe na preursors ebyiri zikorana nubwoko bubiri bwa reseptor ya G-protein, reseptor ya NPFF1 na NPFF2, bifitanye isano ryiza kandi bigira uruhare mubikorwa bitandukanye bya physiologique, nko kugenzura umutima, kugenzura imisemburo, gukora macrophage, thermohomeostasis, no kugabanya ububabare.

Ubuvuzi bwa NPFFA bwibanze kuri proteolyique bwibanze bugomba gutanga peptide irimo NPFF, hamwe na aside aside N-yongeyeho eshatu zitandukanye zitandukanye nubwoko, hamwe na peptide irimo NPSF (SLAAPQRFa), uburebure bwayo buterwa nubwoko.NPFFB yamenyekanye nkibibanziriza peptide ifitanye isano na RFamide (RFRP, izwi kandi nka GnIH ya hormone ikuraho gonadotropine), irimo peptide irimo LPLRFa na peptide isangiye icyerekezo kimwe C-terminal PQRFamide nka NPFF, nka NPVF (VPNLPQRFa).

Sisitemu ya NPFF na opioid yerekanwe gukorana murwego rwinshi, kuva imyitwarire yinyamaswa kugeza kuri molekile ya reseptor.Nociception nigikorwa cyizwe cyane mumikorere ya physiologique yiyi mikoranire, ariko ibihembo, kugenda, kurya no kuva munda nabyo bigira ingaruka.Endogenous opioide irakenewe muburyo bwo gusesengura inshinge za NPFF, kandi peptide ya endogenous NPFF igira uruhare mugikorwa cyo kwihanganira analgesic / hyperalgesia iterwa no kuvura indwara ya opioid idakira.

NPFF kandi igenzura umubare na metabolisme ya macrophage muri tipusi ya adipose, ningirakamaro kubuzima bwimitsi ya adipose