JWH18 Jwh18 5cl Sgt78 7A 7ad Adb S709 CAS 209414-07-3

JWH-018 (1-pentyl-3- (1-naphthoyl) indole, NA-PIMO cyangwa AM-678) ni imiti idakira mu muryango wa naphthoyl indole, igaragara muri CB 1 na CB 2 yakira urumogi, Ifite bimwe guhitamo CB 2. Bitanga ingaruka ku nyamaswa zisa na THC, urumogi ruboneka bisanzwe mu rumogi, bigatuma rukoreshwa mu bicuruzwa by’urumogi, mu bihugu bimwe na bimwe bigurishwa mu buryo bwemewe n’amategeko "impumuro nziza."

Nka agonist yuzuye kuri CB 1 na CB 2 yakira urumogi, iyi nteruro ishyirwa muburyo bwo gusesengura.Ingaruka zo gusesengura urumogi rwitwa urumogi rwahujwe na reseptor ya CB1 rwerekanwe neza mukuvura ububabare bwa neuropathique, ububabare bwa kanseri, na artite.

Izi miti ikora yigana imisemburo isanzwe ya endocannabinoide yumubiri, nka 2-AG na anandamide (AEA), ikora mubinyabuzima kandi ishobora gukomera cyangwa kubuza ibimenyetso bya nervice.Kuberako bike bizwi mubitera ububabare budashira, ubushakashatsi niterambere bigomba gukorwa mbere yuko ubushobozi bwo kuvura ibinyabuzima nkibi biboneka.