Hygromycine A CAS: 6379-56-2 Homomycine
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Ibikoresho bya shimi:
Ifu yera.Acide nkeya.Kubora mumazi n'inzoga.Byakozwe na Streptomyces hygroscopicus.
Ikoreshwa:
Hygromycine A., antibiyotike yirengagijwe, ihitana yica bagiteri itera indwara ya Lyme.Yashoboye kuvura indwara ya Lyme mu mbeba itabangamiye mikorobe.
Ubuvuzi (antibiyotike yagutse).
Ibisobanuro ChEBI: Igicuruzwa gisanzwe kiboneka mu bwoko bwa Streptomyces.
SR 9009 ni synthique REV-ERB agonist igenga imyitwarire ya circadian na metabolism;ifite ubushobozi bwo kuvura indwara ziterwa no gusinzira n'indwara ziterwa na metabolike.Nibintu byayobora icyiciro gishya cyimiti ya kanseri ifitanye isano nisaha yumubiri.
SR9009, izwi kandi nka Stenabolic, nibiyobyabwenge byubushakashatsi nka agonist wa REV-ERB.
REV-ERB-α na REV-ERB-β, ibyakira bibiri bya kirimbuzi, bifite uruhare runini muguhuza imvugo ya proteine yibanze yisaha itwara injyana mubikorwa na metabolism.
Muri vitro: Byombi SR9009 hamwe na SR9011 bisa na byo bishobora kongera urugero-byongera ibikorwa bya repressor biterwa na REV-ERB byasuzumwe mu tugari twa HEK293 byerekana indangagihe ya Gal4 ADN ihuza: REV-ERB ligand ihuza domaine α cyangwa β n'umunyamakuru wa Gal4-witabira luciferase. .Byongeye kandi, SR9009 wasangaga ibasha guhagarika imvugo ya BMAL1 intumwa RNA mumagambo ya HepG2 muburyo bwa REV-ERB-α / β.
Muri vivo: Imbeba zavuwe hamwe numuti umwe wa SR9009, SR9011 cyangwa imodoka mugihe cyumuzingi 6 (CT6 (6h nyuma yumucyo) nyuma yiminsi 12 mubihe D / D byerekana imiterere ya Rev-erb-α. Ibisubizo byerekanaga ko imodoka Gutera inshinge ntago byahungabanije ibikorwa bya moteri ya circadian.Ibinyuranye, imiyoborere yumuti umwe yaba SR9009 cyangwa SR9011 yatumye habaho gutakaza ibikorwa bya lokomoteri mugihe cyumwijima. Byongeye kandi, ibikorwa bisanzwe byagaruye uruziga rukurikiraho, rukaba rwarahuzaga. hamwe no gukuraho ibiyobyabwenge mugihe kitarenze 24h.
