Agonist API GW501516 ifu yera

GW 501516 ni agoniste wa PPARδ ifite EC50 agaciro ka 1.1 nM.
GW501516 yerekanwe ko ari agoniste ikomeye kandi itoranya PPARα izwi na EC 50 ya 1. 1 nM irwanya PPARα hamwe ninshuro 1000 yo guhitamo kurenza ubundi bwoko bwabantu, PPARα na -γ.GW501516 igira ingaruka zo kurwanya inflammatory mu mbeba zifite imiterere ya tubular (mProx).GW501516 ibuza palmitate- na TNFα iterwa no kwiyongera kwa MCP-1 mRNA imvugo muburyo buterwa na dose.
GW501516 itera kwangirika kw'amagufwa, bigatuma BMD igabanuka no kwangirika kw'amagufwa mu mbeba za OVX.GW501516 yongerera umuriro hagati yimyanya ndangagitsina no kwangirika kwingirabuzimafatizo hafi ya poroteyine iremereye imbeba nephropathie.Ubuvuzi bwa GW501516 butezimbere kwihangana no kugereranya dehydrogenase (SDH) -imitsi yimitsi myiza mumbeba zahuguwe kandi zidatojwe.