JWH18 Jwh18 5cl Sgt78 7A 7ad Adb S709 CAS 209414-07-3

JWH-018 (1-pentyl-3-(1-naphthoyl)indole, NA-PIMO kapena AM-678) ndi mankhwala ochepetsa ululu m'banja la naphthoyl indole, lomwe limawonetsedwa mu CB 1 ndi CB 2 cannabinoid receptors, Ili ndi zina. selectivity kwa CB 2. Zimapanga zotsatira za nyama zofanana ndi THC, cannabinoid yomwe imapezeka mwachibadwa mu chamba, zomwe zimatsogolera ku ntchito yake muzinthu zopangidwa ndi cannabis, zomwe m'mayiko ena zimagulitsidwa mwalamulo monga "kusakaniza kununkhira."

Monga agonist wathunthu wa CB 1 ndi CB 2 cannabinoid zolandilira, pawiri iyi imayikidwa ngati mankhwala oletsa ululu.Zotsatira za analgesic za cannabinoid ligands zokhala pakati ndi CB1 zolandilira zawonetsedwa bwino pochiza ululu wa neuropathic, kupweteka kwa khansa, ndi nyamakazi.

Mankhwalawa amagwira ntchito potengera ma endocannabinoid mahomoni omwe amapezeka mwachilengedwe m'thupi, monga 2-AG ndi anandamide (AEA), omwe amagwira ntchito mwachilengedwe ndipo amatha kukulitsa kapena kuletsa kuwonetsa kwa mitsempha.Chifukwa chakuti zochepa zimadziwika ponena za zomwe zimayambitsa kupweteka kosalekeza, kafukufuku wambiri ndi chitukuko chiyenera kuchitidwa kuti mphamvu zochiritsira za mankhwala oterowo zitheke.