Hygromycin A CAS: 6379-56-2 Homomycin

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Chemical Properties:
White ufa.Zofooka acidic.Momasuka sungunuka m'madzi ndi mowa.Wopangidwa ndi Streptomyces hygroscopicus.
Zogwiritsa:
Hygromycin A, mankhwala ophera mabakiteriya amene amanyalanyazidwa, amapha mwapadera mabakiteriya amene amayambitsa matenda a Lyme.Inatha kuchiza matenda a Lyme mu mbewa popanda kusokoneza microbiome.
Mankhwala (ma antibayotiki ambiri).
Tanthauzo: ChEBI: Chopangidwa mwachilengedwe chopezeka mumitundu ya Streptomyces.

SR 9009 ndi rev-ERB agonist yopangidwa yomwe imayendetsa khalidwe la circadian ndi metabolism;imatha kugwiritsidwa ntchito pochiza matenda ogona komanso matenda a metabolic.Ndiwotsogolera gulu latsopano la mankhwala a khansa omwe amagwirizana ndi wotchi ya circadian ya thupi.

SR9009, yomwe imadziwikanso kuti Stenabolic, ndi mankhwala ofufuza ngati agonist wa REV-ERB.
REV-ERB-α ndi REV-ERB-β, zolandilira ziwiri za nyukiliya, zimakhala ndi gawo lofunikira pakuwongolera mafotokozedwe a mapuloteni apakati oyendetsa magalimoto muzochita ndi metabolism.
In vitro: Onse SR9009 ndi analogi SR9011 akhoza kuonjezera modalira mlingo wa REV-ERB-opondereza zochita zoyesedwa m'maselo a HEK293 akuwonetsa chimaeric Gal4 DNA yomangirira domain: REV-ERB ligand binding domain α kapena β ndi Gal4-responsive luciferase reporter. .Kuphatikiza apo, SR9009 idapezeka kuti imatha kupondereza mawu a BMAL1 messenger RNA m'maselo a HepG2 munjira yodalira REV-ERB-α/β.
Mu vivo: Mbewa zinachiritsidwa ndi mlingo umodzi wa SR9009, SR9011 kapena galimoto panthawi ya circadian 6 (CT6 (6h pambuyo pa kuyatsa) pambuyo pa masiku a 12 mu D / D mikhalidwe yomwe ikuwonetsa chiwonetsero chachikulu cha Rev-erb-α. Mosiyana ndi izi, kugwiritsa ntchito mlingo umodzi wa SR9009 kapena SR9011 kunapangitsa kuti ntchito ya locomotor iwonongeke panthawi yamdima wamutuwo. ndi chilolezo cha mankhwala pasanathe 24h.