JWH18 Jwh18 5cl Sgt78 7A 7ad Adb S709 CAS 209414-07-3

Ko te JWH-018 (1-pentyl-3-(1-naphthoyl)indole, NA-PIMO or AM-678) he matū analgesic i roto i te whanau naphthoyl indole, e whakaatuhia ana i roto i te CB 1 me CB 2 nga kaiwhakawhiwhi cannabinoid, He etahi. whiriwhiringa mo CB 2. Ka puta he paanga ki roto i nga kararehe e rite ana ki te THC, he cannabinoid e kitea ana i roto i te cannabis, e arahi ana ki te whakamahi i nga hua tarukino waihanga, i etahi whenua ka hokona i runga i te ture hei "whakaranu kakara."

Ka rite ki te agonist oti mo CB 1 me CB 2 cannabinoid receptors, kua whakarōpūtia tenei pūhui hei analgesic.Ko nga paanga analgesic o nga ligands cannabinoid i takawaenga e nga kaiwhakawhiwhi CB1 kua tino whakaatuhia i roto i te maimoatanga o te mamae neuropathic, te mamae o te mate pukupuku, me te mate pukupuku.

Ko enei puhui e mahi ana ma te peehi i nga homoni endocannabinoid puta noa i te tinana, penei i te 2-AG me te anandamide (AEA), he mahi koiora ka taea te whakakaha, te aukati ranei i te tohu nerve.No te mea he iti noa te mohio mo nga take o te mamae o te mamae, me nui ake te rangahau me te whakawhanaketanga i mua i te mohiotanga o te kaha whakaora o enei momo koiora.