Hua matū Bromazolam CAS 71368-80-4
Nga korero taketake
tātai rāpoi: C17H13BrN4
- Ira whakarewa: 272.0-275℃
- Ira kohua: 519.8±60.0 °C(I Matapaetia)
- kiato: 1.54±0.1 g/cm3 (20 ºC 760 Torr)
- pka: 2.37±0.40(Te Matapae)
- Tātai rāpoi: C17H13BrN4
- Taumaha rāpoi: 353.21600
- Papatipu Tika: 352.03200
- PSA: 43.07000
- Rangitaki: 3.12480
Whakamahinga
Ko te Bromazolam kua whakarōpūhia hei benzodiazepine pukapuka i whakahiato tuatahi i te tau 1976, engari kaore i hokona.I muri mai kua hokona hei rongoa hoahoa, i te tuatahi i tohuhia e te EMCDDA i Sweden i te tau 2016. Ko te bromo hei utu mo te chloro analogue o te alprazolam, he rite ano nga paanga whakararu me te awangawanga.He rite te hanganga o te Bromazolam ki nga benzodiazepines tuku iho, tae atu ki te alprazolam (whakakapi i te chlorine ki te bromine) me te bromazepam (te taapiri o te mowhiti triazole).Ko Alprazolam me te bromazepam he matū Apiti IV i te United States;Ko te bromazolam kaore i tino whakaritea.
Ko te 8-Bromo-1-methyl-6-phenyl-4H-s-triazolo [4,3-a][1,4] ka whakamahia te benzodiazepine ki te ako i te mahi antianxiety, antidepressant me te psychotropics mo te punaha nerve matua.
Tikanga Whakaritenga
I tukinotia ratou ki te pHLS9 (2 mg pūmua /mL), 25 μg/mL Alamethicin (UGT reaction mixture B), 90 mM phosphate buffer (pH 7.4), 2.5 mM mg 2+, 2.5 mM isocitrate, me te 0.6 mM i te 37° C NADP +, 0.9 U/mL isocitrate dehydrogenase, 100 U/mL superoxide dismutase me 0.1 mM acetyl-CoA.Na, 2.5 mM UDP-glucuronic acid (UGT reaction mixture solution A), 40 μM PAPS, 1.2 mM SAM, 1 mM dithiothreitol, 10 mM glutathione, me te 50 μM clobromazolam or Bromazolam i tapiritia.
Tikanga Tauhohenga:50 μM Bromazolam mo te 360min i te 37°C
Nga tono:Bromazolam metabolites ikua tautuhiai roto i te heki pHLS9.