Agonist API GW501516 cerussa
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Consuetudinem
GW 501516 est agonizatio PPARccc cum valore EC50 1.1 nM.
GW501516 ostenditur potentissimum ac selectivum PPAR agonistarum notum ec 50 e 1. 1 nm contra PPARα et 1000 triplicem selectivam in aliis subtypis humanis, PPAR et -γ.GW501516 laborat anti-inflammatorio effectus in mus culta cellulas proximales (mProx) cellulas.GW501516 nia palmitate- et TNFα adducta crescit in MCP-I variant expressio in modo dependens.
GW501516 causat formationis ossis imminutam, ducentes ad diminutionem BMD et depravationem proprietatum ossis in mures OVX.GW501516 inflammationem interstitialem attenuat et damnum cellae proximalis in nephropathia musculorum interdum oneris.GW501516 Curatio cursus patientiam auget et proportio succinatae dehydrogenas (SDH) fibrarum musculorum positivae in utroque murium exercitatis et rudibus.
Specifications
| Nomen commune | GW-501516 | Anglicus nomen | GW501516 |
| CAS numerus | 317318-70-0 | hypothetica pondus | 453.498 |
| density | 1.4±0.1 g/cm3 | ferveret | 584.5±60.0 °C at 760 mmHg |
| hypothetica formula | C21H18F3NO3S2 | liquescens punctum | 134-136°C |
| PSA | 112.96000 | mico punctum | 307.3±32.9 °C |