NEUROPPTIDE FF CAS: 99566-27-5 PHE-LEU-PHE-GLN-PRO-GLN-ARG-PHE AMIDE PHE-LEU-PHE-GLN-PRO-GLN-ARG-PHE-NH2 NPFF NEUROPPTIDE FF
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NPFF Neuropeptide (FLFQPQRFa) bụ anụ mammalian aminated neuropeptide nke dịpụrụ adịpụ na ụbụrụ anụ ahụ ma mara dị ka peptide na-achịkwa mgbu na ọrụ antiopioid na-akpata analgesia nke morphine.
N'ime ụmụ mmadụ, neuropeptide FF peptide bụ mkpụrụ ndụ NPFF kpuchiri ya.Mkpụrụ ndụ ihe nketa abụọ na-etinye ihe nnabata abụọ dị iche iche (NPFF1 na NPFF2) na ụzọ abụọ (NPFFA na NPFFB) ka agbachiela n'ọtụtụ anụmanụ.
Neuropeptide FF (NPFF) na RFamide metụtara peptides nke ndị na-ebu ụzọ abụọ na-emekọ ihe na ụdị abụọ nke G-protein-coupled receptors, NPFF1 na NPFF2 subtypes, nwere ezigbo mmekọrịta ma na-etinye aka na ọrụ dịgasị iche iche nke physiological, dị ka nhazi usoro obi, njikwa homonụ, ịgbalite macrophage, thermohomeostasis, na iwu mgbu.
Ọgwụgwọ nke NPFFA precursor na saịtị proteolytic bụ isi kwesịrị inye peptide nwere NPFF, yana amino acid atọ ọzọ N-terminal dị iche site na ụdị gaa na ụdị, yana peptide nwere NPSF (SLAAPQRFa), ogologo ya dabere na ụdị.Achọpụtara NPFFB dị ka ihe mmalite nke peptide metụtara RFamide (RFRP, makwaara dị ka GnIH nke gonadotropin-suppressing hormone), nwere peptides nwere LPLRFa na peptides na-ekerịta otu C-terminal PQRFamide motif dị ka NPFF, dị ka NPVF (VPNLPQRFa) mmadụ.
Egosiputala usoro NPFF na opioid ka ha na-emekọrịta ihe n'ọtụtụ ọkwa, site na omume anụmanụ ruo na ụmụ irighiri ihe nnabata.Nociception bụ ọrụ physiological nke a kacha mụọ gbasara mmekọrịta a, mana ụgwọ ọrụ, mmegharị, iri nri na mmegharị afọ na-emetụtakwa.A na-achọ opioids endogenous maka ihe analgesic nke ogwu ogwu ogwu nke NPFF, na endogenous NPFF peptides na-etinye aka na usoro nke ndidi analgesic / hyperalgesia nke na-ebute site na ọgwụgwọ opioid na-adịghị ala ala.
NPFF na-ejikwa ọnụọgụ na metabolism nke macrophages na anụ ahụ adipose, nke dị mkpa maka ahụike anụ ahụ adipose.
