Agonist API GW501516 ntụ ntụ ọcha
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GW 501516 bụ agonist nke PPARδ nwere uru EC50 nke 1.1 nM.
E gosipụtara GW501516 ka ọ bụrụ agonists PPARA kachasị ike ma họrọ nke a maara na EC 50 nke 1. 1 nM megide PPARA na 1000-fold selectivity n'elu ụdị ndị ọzọ nke mmadụ, PPARA na -γ.GW501516 na-arụ ọrụ mgbochi mkpali na mkpụrụ ndụ tubular proximal (mProx).GW501516 na-egbochi mmụba nke palmitate na TNFa na okwu MCP-1 mRNA n'ụzọ dabere na dose.
GW501516 na-ebute ọkpụkpụ ọkpụkpụ na-adịghị mma, na-eduga n'ịbelata BMD na mmebi nke ọkpụkpụ na oke OVX.GW501516 na-ebelata mbufụt interstitial yana mmebi cell tubular proximal na ụdị nephropathy òké na-ebufe protein.Ọgwụ GW501516 na-eme ka ntachi obi na-agba ọsọ na oke nke succinate dehydrogenase (SDH) - ezigbo akwara akwara na ụmụ oke a zụrụ azụ na nke a na-azụbeghị.
Nkọwapụta
| Aha nkịtị | GW-501516 | Aha bekee | GW501516 |
| Nọmba CAS | 317318-70-0 | molekụla arọ | 453,498 |
| njupụta | 1.4±0.1 g/cm3 | esi ebe | 584.5± 60.0 °C na 760 mmHg |
| usoro ihe omimi | C21H18F3NO3S2 | ebe agbaze | 134-136°C |
| PSA | 112.96000 | ebe mgbari | 307.3±32.9C |