JWH18 Jwh18 5cl Sgt78 7A 7ad Adb S709 CAS 209414-07-3

JWH-018 (1-pentyl-3-(1-naphthoyl)indole, NA-PIMO lossis AM-678) yog cov tshuaj analgesic hauv tsev neeg naphthoyl indole, uas tau qhia hauv CB 1 thiab CB 2 cannabinoid receptors, Nws muaj qee yam. selectivity rau CB 2. Nws tsim cov teebmeem ntawm cov tsiaj zoo ib yam li THC, ib tug cannabinoid pom nyob rau hauv cannabis, ua rau nws siv nyob rau hauv cov khoom hluavtaws cannabis, uas nyob rau hauv qee lub teb chaws raug muag raws li "siv tshuaj tsw qab."

Raws li kev ua tiav agonist rau CB 1 thiab CB 2 cannabinoid receptors, qhov sib xyaw no tau muab cais ua ib qho tshuaj loog.Cov teebmeem analgesic ntawm cannabinoid ligands kho los ntawm CB1 receptors tau pom zoo hauv kev kho mob neuropathic mob, mob qog noj ntshav, thiab mob caj dab.

Cov tebchaw no ua haujlwm los ntawm kev ua raws li lub cev cov tshuaj hormones endocannabinoid uas tshwm sim, xws li 2-AG thiab anandamide (AEA), uas muaj kev lom zem thiab tuaj yeem ua kom hnyav lossis cuam tshuam cov paj hlwb.Vim tias me ntsis paub txog qhov ua rau mob mob ntev, kev tshawb fawb thiab kev loj hlob ntxiv yuav tsum tau ua ua ntej qhov kev kho mob ntawm cov tshuaj lom neeg zoo li no tuaj yeem ua tiav.