Agonist API GW501516 hmoov dawb
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GW 501516 yog agonist ntawm PPARδ nrog EC50 tus nqi ntawm 1.1 nM.
GW501516 tau pom tias yog qhov muaj zog tshaj plaws thiab xaiv PPARα agonists paub nrog EC 50 ntawm 1. 1 nM tiv thaiv PPARα thiab 1000-fold selectivity dua lwm tus tib neeg subtypes, PPARα thiab -γ.GW501516 exerts anti-inflammatory teebmeem nyob rau hauv nas cultured proximal tubular (mProx) cell.GW501516 inhibits palmitate- thiab TNFα-induced nce hauv MCP-1 mRNA qhia nyob rau hauv ib koob tshuaj.
GW501516 ua rau cov pob txha tsis zoo, ua rau BMD txo qis thiab ua kom cov pob txha tsis zoo hauv OVX nas.GW501516 attenuates interstitial o thiab proximal tubular cell puas nyob rau hauv cov protein-overload nas nephropathy qauv.GW501516 kev kho mob txhim kho kev ua haujlwm siab thiab qhov kev faib ua feem ntawm succinate dehydrogenase (SDH) - cov leeg nqaij zoo hauv ob qho tib si kawm thiab tsis tau kawm.
Specifications
| Hom npe | GW-501516 | English npe | wb 501516 |
| CAS nr | 317318-70-0 | molecular hnyav | 453.498 ib |
| ceev | 1.4 ± 0.1g / cm3 | kub point | 584.5 ± 60.0 ° C ntawm 760 mmHg |
| molecular formula | C21H18F3NO3S2 | melting point | 134-136 ° C |
| PSA | 112.96.000 Nws | flash point | 307.3 ± 32.9 ° C |