Cov khoom siv tshuaj Bromazolam CAS 71368-80-4
Cov ntaub ntawv yooj yim
Cov mis mos molecular: C17H13BrN4
- Melting point: 272.0-275 ℃
- Kub taw tes: 519.8 ± 60.0 ° C (Predicted)
- Qhov ceev: 1.54 ± 0.1 g / cm3 (20 ºC 760 Torr)
- Pka: 2.37 ± 0.40 (Predicted)
- Cov roj formula: C17H13BrN4
- Molecular Luj: 353.21600
- PIB: 352.03200
- PIB: 43.0700
- PIB: 3.12480
Kev siv
Bromazolam yog cais raws li ib tug tshiab benzodiazepine uas yog thawj synthesized nyob rau hauv 1976, tab sis tsis tau ua lag luam.Tom qab ntawd nws tau raug muag raws li cov tshuaj tsim qauv, thawj zaug tau txheeb xyuas los ntawm EMCDDA hauv Sweden hauv 2016. Nws yog bromo es tsis txhob siv cov tshuaj chloro analogue ntawm alprazolam, thiab muaj cov nyhuv sedative thiab anxiolytic zoo sib xws.Bromazolam yog cov qauv zoo ib yam li cov tshuaj benzodiazepines, suav nrog alprazolam (hloov cov tshuaj chlorine nrog bromine) thiab bromazepam (ntxiv cov nplhaib triazole).Alprazolam thiab bromazepam yog Schedule IV tshuaj nyob rau hauv lub tebchaws United States;bromazolam tsis tau teem sijhawm meej.
8-Bromo-1-methyl-6-phenyl-4H-s-triazolo[4,3-a][1,4] benzodiazepine yog siv los kawm txog kev ua kom muaj kev ntxhov siab, tshuaj tiv thaiv kev nyuaj siab thiab kev puas siab puas ntsws rau lub hauv paus paj hlwb.
Txoj Kev Npaj
Lawv tau kho nrog pHLS9 (2 mg protein / mL), 25 μg / mL Alamethicin (UGT cov tshuaj tiv thaiv sib xyaw B), 90 mM phosphate buffer (pH 7.4), 2.5 mM mg 2 +, 2.5 mM isocitrate, thiab 0.6 mM ntawm 37 °. C NADP +, 0.9 U/mL isocitrate dehydrogenase, 100 U/mL superoxide dismutase thiab 0.1 mM acetyl-CoA.Tom qab ntawd, 2.5 mM UDP-glucuronic acid (UGT cov tshuaj tiv thaiv sib tov A), 40 μM PAPS, 1.2 mM SAM, 1 mM dithiothreitol, 10 mM glutathione, thiab 50 μM clobromazolam lossis Bromazolam tau ntxiv.
Cov xwm txheej tshwm sim:50 μM Bromazolam rau 360min hauv 37 ° C
Daim ntawv thov:Bromazolam metabolites yogtxheeb xyuashauv pHLS9 incubation.