NEUROPEPTIDE FF CAS:99566-27-5 PHE-LEU-PHE-GLN-PRO-GLN-ARG-PHE AMIDE PHE-LEU-PHE-GLN-PRO-GLN-ARG-PHE-NH2 NPFF NEUROPEPTIDE FF

NPFF Neuropeptide (FLFQPQRFa) he mammalian aminated neuropeptide i hoʻokaʻawale mua ʻia mai ka lolo pipi a ʻike ʻia he peptide hoʻoponopono ʻeha me ka hana antiopioid i ka analgesia i hoʻokomo ʻia i ka morphine.

I loko o ke kanaka, ua hoʻopili ʻia ka peptide FF neuropeptide e ka NPFF gene.ʻElua mau genes e hoʻopili ana i ʻelua mau mea hoʻokipa like ʻole (NPFF1 a me NPFF2) a me ʻelua precursors (NPFFA a me NPFFB) i hoʻopili ʻia i loko o kekahi mau mammals.

ʻO Neuropeptide FF (NPFF) a me RFamide pili peptides i hoʻokuʻu ʻia e ʻelua precursors e launa pū me nā subtypes ʻelua o G-protein-coupled receptors, nā subtypes NPFF1 a me NPFF2, me ka pilina maikaʻi a pili i nā ʻano hana physiological, e like me ka hoʻoponopono cardiovascular, ka mālama ʻana i ka hormone, ka hoʻoulu ʻana o ka macrophage, ka thermohomeostasis, a me ka hoʻoponopono ʻeha.

ʻO ka mālama ʻana i ka NPFFA precursor ma ke kahua proteolytic kumu e hāʻawi i kahi peptide i loaʻa i ka NPFF, me ʻekolu mau ʻakika amino N-terminal e ʻokoʻa ana mai kēlā me kēia ʻano, a me kahi peptide i loaʻa ka NPSF (SLAAPQRFa), nona ka lōʻihi e pili ana i nā ʻano.Ua ʻike ʻia ʻo NPFFB ʻo ia ka precursor o RFamide pili peptide (RFRP, i ʻike ʻia ʻo GnIH o ka gonadotropin-suppressing hormone), loaʻa nā peptides i loaʻa iā LPLRFa a me nā peptides e kaʻana like ana i ka C-terminal PQRFamide motif me NPFF, e like me NPVF (VPNLPQRFa) kanaka.

Ua hōʻike ʻia nā ʻōnaehana NPFF a me nā opioid e launa pū ma nā pae he nui, mai ka hana holoholona a i nā molekala ʻae.ʻO Nociception ka hana physiological i aʻo nui ʻia o kēia pilina, akā pili pū ka uku, neʻe, ʻai a me ka neʻe ʻana o ka ʻōpū.Pono nā opioids endogenous no nā waiwai analgesic o ka spinal injection o NPFF, a ua komo nā peptides NPFF endogenous i ke kaʻina hana o ka hoʻomanawanui analgesic / hyperalgesia i hoʻoulu ʻia e ka lāʻau opioid mau.

Hoʻoponopono pū ʻo NPFF i ka helu a me ka metabolism o nā macrophages i loko o ka ʻiʻo adipose, he mea nui ia no ke olakino o ke kino