JWH18 Jwh18 5cl Sgt78 7A 7ad Adb S709 CAS 209414-07-3

ʻO JWH-018 (1-pentyl-3-(1-naphthoyl)indole, NA-PIMO a i ʻole AM-678) kahi mea analgesic i loko o ka ʻohana naphthoyl indole, i hōʻike ʻia ma CB 1 a me CB 2 cannabinoid receptors. koho no CB 2. Hoʻopuka ia i nā hopena i nā holoholona e like me THC, kahi cannabinoid i loaʻa maoli i ka cannabis, e alakaʻi ana i kona hoʻohana ʻana i nā huahana cannabis synthetic, i kūʻai ʻia ma ke kānāwai ma ke ʻano he "hui ʻala."

Ma ke ʻano he agonist piha no CB 1 a me CB 2 cannabinoid receptors, ua helu ʻia kēia pūhui he analgesic.Ua hōʻike maikaʻi ʻia nā hopena analgesic o nā ligands cannabinoid i hoʻopaʻa ʻia e nā mea hoʻokipa CB1 i ka mālama ʻana i ka ʻeha neuropathic, ka ʻeha maʻi maʻi, a me ka ʻāʻī.

Ke hana nei kēia mau pūhui ma ka hoʻohālike ʻana i nā hormones endocannabinoid kūlohelohe o ke kino, e like me 2-AG a me anandamide (AEA), he mea olaola a hiki ke hoʻoikaika a pale i ka hōʻailona nerve.Ma muli o ka liʻiliʻi o ka ʻike e pili ana i nā kumu o ka ʻeha mau ʻana, pono e hana hou ʻia ka noiʻi a me ka hoʻomohala ʻana ma mua o ka hiki ke hoʻokō ʻia ka hiki ke hoʻōla ʻia o ia mau mea olaola.