Hygromycin A CAS:6379-56-2 Homomycin

Hoʻokaʻaʻike mai iaʻu:

Email:salesexecutive1@yeah.net

Whatsapp: + 8618931626169

Wickr:liliwang

Nā waiwai kemika:
Pauda keʻokeʻo.ʻAkaʻaka nāwaliwali.Hiki ke hoʻoheheʻe ʻia i ka wai a me ka waiʻona.Hana ʻia e Streptomyces hygroscopicus.
Hoʻohana:
ʻO Hygromycin A, he lāʻau lāʻau i mālama ʻole ʻia, e pepehi wale i ka maʻi bacteria e hoʻokumu ai i ka maʻi Lyme.Ua hiki iā ia ke mālama i ka maʻi Lyme i nā ʻiole me ka hoʻopilikia ʻole i ka microbiome.
Ka lāʻau lapaʻau (broad-spectrum antibiotic).
Wehewehe ChEBI: He huahana kūlohelohe i loaʻa i nā ʻano Streptomyces.

ʻO SR 9009 kahi agonist REV-ERB synthetic e hoʻoponopono i ka hana circadian a me ka metabolism;hiki ke hoʻohana i ka mālama ʻana i nā maʻi moe a me nā maʻi metabolic.He hui alakaʻi ia no ka papa hou o nā lāʻau lapaʻau e pili ana i ka uaki circadian o ke kino.

ʻO SR9009, i kapa ʻia ʻo Stenabolic, kahi lāʻau noiʻi e like me ka agonist o REV-ERB.
ʻO REV-ERB-α a me REV-ERB-β, ʻelua mau mea hoʻokipa nuklea, he kuleana koʻikoʻi i ka hoʻoponopono ʻana i ka hōʻike ʻana o nā protein clock clock e hoʻokele ana i nā mele i ka hana a me ka metabolism.
In vitro: Hiki i ka SR9009 a me kāna analog SR9011 ke hoʻonui i ka hana repressor hilinaʻi REV-ERB i loiloi ʻia i loko o nā cell HEK293 e hōʻike ana i kahi chimaeric Gal4 DNA binding domain: REV-ERB ligand binding domain α a i ʻole β a me kahi mea hoʻolaha luciferase pane Gal4 .Eia hou, ua ʻike ʻia ʻo SR9009 e hiki ke hoʻopau i ka hōʻike RNA messenger BMAL1 i nā cell HepG2 ma kahi ʻano REV-ERB-α / β.
In vivo: Ua mālama ʻia nā ʻiole me ka nui o SR9009, SR9011 a i ʻole kaʻa i ka manawa circadian 6 (CT6 (6h ma hope o nā kukui) ma hope o 12 mau lā i nā kūlana D/D e hōʻike ana i ka hōʻike kiʻekiʻe o Rev-erb-α. ʻAʻole i hoʻopilikia ʻia ka hana locomotor circadian. I ka hoʻokaʻawale ʻana, ʻo ka hoʻohana ʻana i hoʻokahi kaila o SR9009 a i ʻole SR9011 ua alakaʻi i ka nalowale o ka hana locomotor i ka wā pōʻeleʻele o ke kumuhana. me ka hoʻomaʻemaʻe ʻana i nā lāʻau ma lalo o 24h.