Prostaglandins Hua kemika 99% maʻemaʻe API Material Lumigan Bimatoprost CAS 155206-00-1 no ka mālama ʻana i ka maka
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Hoʻohana
ʻO ka Bimatoprost kahi lāʻau prostaglandin i hoʻohana mua ʻia e mālama i nā maʻi maka e like me ka glaucoma.ʻO Lumigan ka inoa lāʻau.Eia nō naʻe, i ka wā o ka mālama ʻana, ua ʻike ʻole ka mea maʻi ua piʻi nui ke anawaena, ka lōʻihi a me ka nui o kona mau maka.Ma hope, ua hoʻohana ʻia ka bimatoprost i nā hoʻokolohua lapaʻau no ka nani o ka maka.ʻO kona hopena nui i ka mānoanoa a me ka mānoanoa o nā maka i alakaʻi pololei ʻia i ka hoʻomaka ʻana o Lattise e ka hui hana ʻo Lumegen, ʻo Allergan.Ua hoʻokuʻu ʻia ka lāʻau lapaʻau i Dekemaba 2008. Ua ʻae ʻia e ka US FDA, ua lilo ia i huahana ʻoihana no ka ʻeleʻele a me ka mānoanoa o nā maka.
I Iulai 2006, ua ʻae ʻia e ka United States Allergan Co., Ltd. ka bimatoprost-timolol maleate maleate compound eye drops e ka mana lāʻau lapaʻau EU no ka hōʻemi ʻana i ka pane i ka hoʻohana hoʻokahi β-receptor blockers a i ʻole prostaglandins.ʻO ke kaomi intraocular a i ʻole ke kiʻekiʻe o ka ocular i nā maʻi me ka glaucoma open-angle ʻaʻole i pane kūpono i ka analogue therapy.Aia ka kulu maka hui 0.0Chemicalbook3% bimatoprost a me 0.5% timolol maleate, hoʻokahi manawa i ka lā, hiki iā ia ke hāʻawi i ka hopena hoʻokele intraocular maikaʻi loa, a ʻoi aku ka maikaʻi ma mua o ka bimatoprost wale nō.Matoprost a i ʻole timolol maleate.Ua hōʻoia ʻia nā hoʻokolohua lapaʻau he hiki ke hoʻomanawanui maikaʻi ka lāʻau, me ka hōʻemi ʻana o 40% i ka nui o ka hyperemia ocular i hoʻohālikelike ʻia me ka bimatoprost wale nō.
No ka mālama ʻana i ka glaucoma, hiki ke hoʻohana ʻia i ka wai ulu o ka eyelash, ʻo 0.03% ka manaʻo.
Nā kikoʻī
| inoa mea kūʻai | Bimatoprost |
| CAS | 155206-00-1 |
| ʻO ka mānoanoa | 1.1 ± 0.1 g/cm3 |
| Lae paila | 629.8 ± 55.0 ° C AT 760 mmHg |
| Lae hehee | 66-68 ° C |
| Molekala | C25H37NO4 |
| Kaumaha molekula | 415.566 |
| Kuhikuhi uila | 334.7 ± 31.5 ° C |
| Pono Pono | 415.272247 |
| PSA | 89.79000 |
| Logp | 1.98 |
| Ka nana aku | Paʻa Crystal |
| Pumi mahu | 0.0 ± 1.9 mmHg AT 25 ° C |
| Hōʻike hōʻike | 1.591 |
| Nā kūlana mālama | 20 ° C |
Kekahi Bimatoprost CAS 155206-00-1 Noiʻi:
Ua kūpono ʻo Olaparib i ka Brca1;p53 maʻi umauma umauma (50mg/kg intraperitoneal injection i kēlā me kēia lā), akā ʻaʻohe hopena i ka HR-deficient Ecad;p53 umauma maʻi.ʻAʻohe o Olaparib i mea ʻawaʻawa e kaupalena ʻia ana i nā ʻiole e lawe ana i ka maʻi tumora.Ua hoʻohana ʻia ʻo Olaparib e mālama i nā ʻōpū me nā hoʻololi BRCA, e like me ke kanesa ovarian, ka maʻi maʻi umauma, a me ka maʻi maʻi prostate.Eia kekahi, ua hoʻokaʻawale ʻo Olaparib i nā pūnaewele maʻi maʻi ATM-deficient, me ka manaʻo e hiki ke hoʻohana ʻia ʻo Olaparib i mea hiki ke hoʻohana ʻia no ka mālama ʻana i nā maʻi maʻi lymphoid ATM-mutated.
ʻO Olaparib kahi mea paʻa PARP e hana kūʻē i ka BRCA1 a i ʻole BRCA2 mutations.He liʻiliʻi ka hopena o Olaparib i ka tanky (polymer) enzyme-1, a ʻoi aku ka waiwai o ka IC50 ma mua o kēlā.Hana ʻo Olaparib ma kahi ʻano o 30-100nM i nā cell SW620 e hoʻopau i ka PARP-1.ʻO nā laina kelepona hemahema BRCA1 (MDA-MB-463[1] a me HCC1937) he hypersensitive iā Olaparib i hoʻohālikelike ʻia me BRCA1- a me BRCA2- lawa nā laina cell (Hs578T,MDA-MB-23,T47D) ʻO Olaparib ka mea e kāohi ai i ka PARP a poloka i ka hoʻoponopono hoʻoponopono. , ka hopena i ka naʻau ikaika o nā cell KB2P iā Olaparib.ʻO ka hopena, ʻo ia ka hoʻololi ʻana o nā ʻokiʻoki hoʻokahi i nā haki pālua i ka wā o ka hoʻopiʻi ʻana o DNA, a laila e hoʻāla ai i ke ala hoʻohui hou ʻana iā BRCA2.
ʻO ka Bimatoprost kahi synthetic prostamide F2α derivative, hiki iā ia ke hoʻohālikelike i ka hopena o ka prostamine i hana ʻia i loko o ke kino, hoʻonui i ka nui o ka hana ʻana o ka wai hoʻokaʻawale, hoʻemi i ke kūʻē ʻana o ka wai hoʻoheheʻe wai, a hoʻonui i ke kahawai trabecular network a me ka uveal sclera. ʻo ia ka lāʻau anti-glaucoma kūloko me ka hopena ikaika loa i ka hōʻemi ʻana i ke kaomi intraocular.He kūpono ia no ka mālama ʻana i ka glaucoma open-angle (POAG) a i ʻole ka ʻike maka kiʻekiʻe i kūpono ʻole me nā lāʻau hoʻohaʻahaʻa hoʻohaʻahaʻa intraocular.ʻO nā poʻe maʻi maʻi kiʻekiʻe (OHT).
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