Xylazine CAS NO: 7361-61-7 Rompun, Anased, Sedazine, Chanazine

Amfani da likita
Toluene thiazide ana yawan amfani dashi azaman maganin kwantar da hankali, shakatawa na tsoka da analgesic.Ana yawan amfani da ita don maganin tetanus.Xylazine yayi kama da kwayoyi irin su phenothiazine, tricyclic antidepressants da clonidine.A matsayin maganin sa barci, ana amfani dashi akai-akai tare da ketamine.Xylazine ya bayyana yana rage jin daɗin jiki ga insulin da ɗaukar glucose.Yohimbine shine alpha2 adrenergic antagonist mai karɓa wanda aka yi amfani dashi don rage matakan glucose zuwa matakan lafiya.Yohimbine yana juyar da illolin toluene thiazide a cikin wurin asibiti idan an gudanar da shi ta cikin jini jim kaɗan bayan an ba da toluene thiazide.

pharmacodynamics

Xylazine shine alpha 2 adrenergic agonist mai ƙarfi.Toluene thiazide da sauran alpha2 adrenergic agonists ana rarraba su cikin jiki a cikin mintuna 30-40 lokacin da aka ba su.Saboda girman lipophilicity ɗin sa, toluene thiazide kai tsaye yana ƙarfafa masu karɓar α2 na tsakiya da kuma masu karɓar αadrenergic na gefe a cikin kyallen takarda iri-iri.A matsayin agonist, toluene thiazide yana haifar da raguwar neurotransmission na norepinephrine da dopamine a cikin tsarin juyayi na tsakiya.Yana yin haka ta hanyar kwaikwayon ɗaurin norepinephrine zuwa masu karɓar autoreceptors a saman presynaptic, wanda ke haifar da hana amsawar norepinephrine.

Xylazine kuma yana aiki azaman mai hana sufuri ta hanyar hana aikin sufuri na norepinephrine ta hanyar gasa ta hana zirga-zirgar ƙasa.Don haka, toluene thiazide ya ƙaru sosai K m kuma bai shafi V max ba.Wannan na iya faruwa ta hanyar yin hulɗa kai tsaye tare da yankuna waɗanda suka zo tare da wuraren dauri na antidepressant.Misali, toluene thiazide da clonidine suna hana ɗaukar MIBG (analog ɗin norepinephrine) ta ƙwayoyin neuroblastoma.Xylazine yana da alaƙa daban-daban don cholinergic, serotonergic, dopaminergic, alpha1, adrenergic, H 2-histamine, da masu karɓar opioid.Tsarin sinadaransa yayi kama da na phenothiazines, tricyclic antidepressants da clonidine.