NEuropeptIDE FF CAS: 99566-27-5 PHE-LEU-PHE-GLN-PRO-GLN-ARG-PHE AMIDE PHE-LEU-PHE-GLN-PRO-GLN-ARG-PHE-NH2 NPFF NEUROPPTIDE FF
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NPFF Neuropeptide (FLFQPQRFa) wani mammalian ne wanda aka haifa neuropeptide wanda ya keɓe daga kwakwalwar bovine kuma an kwatanta shi azaman peptide mai raɗaɗi tare da aikin antiopioid zuwa analgesia mai haifar da morphine.
A cikin mutane, neuropeptide FF peptide an sanya shi ta hanyar NPFF gene.Kwayoyin halitta guda biyu da ke ɓoye masu karɓa daban-daban guda biyu (NPFF1 da NPFF2) da magabatan biyu (NPFFA da NPFFB) an rufe su a cikin dabbobi masu shayarwa da yawa.
Neuropeptide FF (NPFF) da RFamide da ke da alaƙa da peptides waɗanda aka fitar da su ta hanyar magabatan biyu suna hulɗa tare da nau'ikan nau'ikan nau'ikan G-protein-coupled receptors, NPFF1 da NPFF2 subtypes, tare da kyakkyawar alaƙa kuma suna shiga cikin nau'ikan ayyukan ilimin lissafi, kamar tsarin tsarin zuciya, sarrafa hormone, kunnawa macrophage, thermohomeostasis, da tsarin jin zafi.
Jiyya na NPFFA precursor a ainihin wurin proteolytic yakamata ya samar da peptide mai ɗauke da NPFF, tare da ƙarin amino acid N-terminal guda uku waɗanda suka bambanta daga nau'in zuwa nau'in, da kuma peptide mai ɗauke da NPSF (SLAAPQRFa), wanda tsayinsa ya dogara da nau'in.An gano NPFFB a matsayin madaidaicin RFamide peptide (RFRP, wanda kuma aka sani da GnIH na gonadotropin-suppressing hormone), dauke da peptides dauke da LPLRFa da peptides da ke raba C-terminal PQRFamide motif kamar NPFF, kamar NPVF (VPNLPQRFa) mutum.
An nuna tsarin NPFF da opioid don yin hulɗa a matakan da yawa, daga halayyar dabba zuwa kwayoyin masu karɓa.Nociception shine aikin da aka fi nazarin ilimin halittar jiki na wannan hulɗar, amma lada, motsi, ci da motsin hanji shima yana shafa.Ana buƙatar opioids na endogenous don abubuwan analgesic na allurar kashin baya na NPFF, kuma peptides na NPFF na endogenous suna da hannu a cikin aiwatar da juriya na analgesic / hyperalgesia da aka haifar ta hanyar jiyya na opioid na yau da kullun.
NPFF kuma tana sarrafa lamba da metabolism na macrophages a cikin adipose tissue, wanda ke da mahimmanci ga lafiyar nama mai adipose.
