Hygromycin A CAS: 6379-56-2 Homomycin

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Abubuwan Sinadarai:
Farin foda.Rashin acidic.Da yardar kaina mai narkewa cikin ruwa da barasa.Streptomyces hygroscopicus ne ya samar.
Amfani:
Hygromycin A, kwayoyin da ba a kula da su ba, yana kashe kwayoyin cutar da ke haifar da cutar Lyme.Ya sami damar magance cutar Lyme a cikin beraye ba tare da rushe microbiome ba.
Magunguna (maganin rigakafi mai faɗi).
Ma'anar ChEBI: Samfurin halitta da aka samo a cikin nau'in Streptomyces.

SR 9009 shine agonist na REV-ERB na roba wanda ke daidaita halayen circadian da metabolism;yana da yuwuwar amfani a cikin maganin cututtukan bacci da cututtukan rayuwa.Yana da sinadarin gubar don sabon nau'in magungunan kansar da ke da alaƙa da agogon circadian na jiki.

SR9009, kuma aka sani da Stenabolic, magani ne na bincike azaman agonist na REV-ERB.
REV-ERB-a da REV-ERB-β, masu karɓar makaman nukiliya guda biyu, suna da muhimmiyar rawa wajen daidaita maganganun sunadaran agogo na motsa jiki a cikin aiki da metabolism.
A cikin vitro: Dukansu SR9009 da analog ɗin sa na SR9011 na iya dogaro da dogaro da haɓaka ayyukan mai dogaro da REV-ERB da aka tantance a cikin sel HEK293 suna bayyana yanki mai ɗaure DNA na chimaeric Gal4: REV-ERB ligand binding domain α ko β da Gal4 mai amsa luciferase mai ba da rahoto. .Bugu da ƙari, an gano SR9009 don iya hana BMAL1 manzo RNA magana a cikin kwayoyin HepG2 a cikin hanyar REV-ERB-α / β-dogara.
A cikin vivo: An bi da mice tare da kashi ɗaya na SR9009, SR9011 ko abin hawa a lokacin circadian 6 (CT6 (6h bayan hasken wuta) bayan kwanaki 12 a cikin yanayin D / D da ke nuna alamar bayyanar Rev-erb-α. Sakamakon ya nuna cewa abin hawa allura ba ta haifar da rushewa ba a cikin ayyukan locomotor na circadian.Ya bambanta, gudanar da kashi ɗaya na SR9009 ko SR9011 ya haifar da asarar ayyukan locomotor a lokacin yanayin duhu. tare da kawar da magungunan a cikin ƙasa da 24h.