Agonist API GW501516 farin foda

GW 501516 agonist ne na PPARδ tare da ƙimar EC50 na 1.1 nM.
GW501516 an nuna shi ya zama mafi ƙarfi da zaɓaɓɓen agonists na PPARA da aka sani tare da EC 50 na 1. 1 nM akan PPARA da 1000-ninka zaɓi akan sauran nau'ikan ɗan adam, PPARA da -γ.GW501516 yana yin tasirin anti-mai kumburi a cikin ƙwayoyin tubular proximal na linzamin kwamfuta (mProx).GW501516 yana hana palmitate- da TNFa-induced karuwa a cikin MCP-1 mRNA magana ta hanyar dogaro da kashi.
GW501516 yana haifar da lalacewar samuwar kashi, yana haifar da raguwar BMD da lalacewar kaddarorin kashi a cikin berayen OVX.GW501516 yana rage kumburin tsaka-tsaki da lalacewar ƙwayoyin tubular kusa a cikin ƙirar nephropathy na linzamin kwamfuta mai ɗaukar nauyi.GW501516 jiyya yana haɓaka juriyar gudu da kuma adadin succinate dehydrogenase (SDH) - tabbataccen ƙwayoyin tsoka a cikin ƙwararrun ƙwararrun ƙwaya da marasa horo.